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Shopping for pharmaceutical reviewWhen you’re shopping for pharmaceutical review you’ve come to the right place. We’re specialists in this pharmaceutical review field. You can’t find exactly what you’re looking for on too many other sites, but you can here. Well maybe that’s a slight exaggeration. We might not have got exactly what you’re looking for – pharmaceutical review – but we know the very best websites to get it from. All you have to do is follow the links below. They’re the very best pharmaceutical review sites you’re going to find anywhere, and they’re the ones we use ourselves when we want to get information or make a purchase. How do we know they’re the best pharmaceutical review websites available on the net today? Because we’ve spent months painstakingly researching the subject. We’ve visited every site about pharmaceutical review we could find, and we’ve studied them to sort the good from the bad. Look, we’re good at getting ranked well in search engines. pharmaceutical review might be our big interest, but we’ll be the first to admit that out site doesn’t come anywhere near the quality of the websites we’re linking to. So what we suggest you do is follow one the links. You won’t be disappointed. Thanks for visiting our webpage, and please come back again one day. Next time you visit you might find that we’re the best pharmaceutical review place online. New Findings on the Role of Glutathione in Cancer by: Priya F Shah
Cancer cells and normal cells are known to respond differently to nutrients and drugs that affect glutathione status. Numerous studies have shown that tumor cells have elevated levels of glutathione levels, which confers resistance to chemotherapy drugs. One of the challenges of cancer therapy is how to deplete tumor cells of glutathione, so as to make them more vulnerable to the effects of chemotherapy drugs, while at the same time allowing normal cells to remain relatively unaffected by chemotherapeutic drugs. A number of new findings have emerged that take into consideration the role of glutathione in pathways that promote programmed cell death (apoptosis) in cancer cells. A German study has reported that glutathione (GSH) plays a critical role in cellular mechanisms that result in cell death. The study found that cancer cells resistant to apoptosis had higher intracellular GSH levels. Depletion of glutathione in these tumor cells made them more vulnerable to the effects of anticancer drugs or the gene that promotes apoptosis (CD95 or APO-1/Fas). The researchers concluded that apoptosis resistance in tumor cells depends, at least in part, on intracellular GSH levels. (1) In another study conducted in Spain, researchers found that lowering GSH concentration may be convenient not only for the efficiency of chemotherapy, but also to induce a rather fast and direct apoptosis mechanism in tumor cells. (2) Based on that premise that the glutathione-S-transferase enzyme is expressed at high levels in many tumors, researchers at the Fox Chase Cancer Center in Pennsylvania, went on to design a novel prodrug (PABA/NO). The glutathione-s-transferase in tumor cells converts PABA/NO to lethal nitric oxide, resulting in death of the tumor cell. The prodrug was shown to have antitumor effects in an animal model for human ovarian cancer. (3) In the fourth study, Polish researchers found that ingesting a selenium supplement is beneficial, as a supportive element in chemotherapy. (4) Selenium is a co-factor of the enzyme glutathione peroxidase [GSH-P(x)] and was found to significantly increase the activity of GSH-P(x) in patients reciving the supplement. A previous clinical study by the same researchers recommended the administration of selenium in patients with ovarian cancer undergoing multi-drug chemotherapy. (5) Another interesting study by researchers in Texas showed that your chances of surviving a type of brain cancer, called primary malignant glioma, could depend on the type of glutathione-s-transferase (GST) gene you were born with. Having a combination of a two specific variants of GST (germ-line GSTP1*A/*A and GSTM1 null genotype) confers a survival advantage in some types of brain cancers, but also comes with an increased risk of adverse events related to chemotherapy. (6) There is compelling evidence to suggest a crucial role for glutathione and substances that target glutathione metabolism in the prevention and treatment of cancer. Undenatured whey protein is one of the natural foods known to selectively deplete cancer cells of their glutathione, thus making them more susceptible to such cancer treatments as radiation and chemotherapy. For a complete report on the research on undenatured whey protein and cancer see the report Glutathione (GSH) and Whey Protein in Cancer. http://www.1whey2health.com/cancer_glutathione.htm Disclaimer: The information here is not provided by medical professionals and is not intended as a substitute for medical advice. Please consult your physician before beginning any course of treatment. References: 1. Friesen C et al. [Cell Death and Differentiation advance online publication, 23 April 2004] 2. Tormos C et al. [Cancer Lett. 2004 May 10;208(1):103-13.] 3. Findlay VJ et al. [Mol Pharmacol. 2004 May;65(5):1070-9.] 4. Sieja K et al. [Gynecol Oncol. 2004 May;93(2):320-327.] 5. Sieja K. [Pharmazie. 1998 Jul;53(7):473-6.] 6. Okcu MF et. al. [Clin Cancer Res. 2004 Apr 15;10(8):2618-25.] Copyright © 2004 Priya Shah
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